Description

(R)-n-Fmoc-Allylglycine is a non-proteinogenic, Fmoc-protected amino acid derivative featuring an allyl side chain in the (R)-configuration. This compound is a critical high-purity building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of unique structural and functional elements. It is primarily utilized by pharmaceutical researchers and peptide manufacturers engaged in drug discovery, development of bioactive compounds, and advanced materials science.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of custom peptides with specific stereochemistry.
• Peptidomimetic Drug Discovery: Used to incorporate the allylglycine moiety into novel drug candidates, potentially modulating receptor binding and metabolic stability.
• Chemical Biology Probes: Serves as a precursor for synthesizing labeled or modified peptides used in studying protein-protein interactions and enzyme mechanisms.
• Material Science: Can be polymerized or incorporated into polymers to create functional biomaterials with tailored properties.
• Academic & Industrial Research: Essential for research in medicinal chemistry, organic synthesis, and the development of new synthetic methodologies.

Basic Information

Product Name	(R)-n-Fmoc-Allylglycine
CAS No.	170642-28-1
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	(R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid; Fmoc-(R)-Allylglycine-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-allylglycine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid; D-Fmoc-allylglycine; Fmoc-D-2-amino-4-pentenoic acid
EINECS	Contact for details

Quality Control

Our (R)-n-Fmoc-Allylglycine is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material for GMP-grade applications upon request and with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.