Description

Acyline CAS NO 170157-13-8 is a potent, selective, and competitive peptide antagonist of gonadotropin-releasing hormone (GnRH) receptors. This compound is of significant value in biochemical and pharmacological research for its ability to effectively block GnRH activity. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on endocrinology, reproductive biology, and oncology drug discovery.

Application

• Endocrine and Reproductive Research: Used as a standard GnRH antagonist to study the hypothalamic-pituitary-gonadal axis, hormone regulation, and reproductive function.
• Preclinical Drug Development: Serves as a critical tool compound for validating new therapeutic targets related to hormone-dependent conditions.
• In Vitro Bioassays: Employed in cell-based assays and receptor binding studies to screen for novel GnRH modulators or to characterize receptor-ligand interactions.
• Animal Model Studies: Utilized to create chemical castration or hormone-suppression models for research in prostate cancer, endometriosis, and other hormone-sensitive diseases.
• Biochemical Standard: Acts as a high-purity reference standard for analytical method development and quality control in peptide synthesis.

Basic Information

Product Name	Acyline
CAS No.	170157-13-8
Molecular Formula	C₈₀H₁₂₈N₂₄O₁₈
Molecular Weight	1698.0 g/mol
Synonyms	Ac-D2Nal-D4Cpa-D3Pal-Ser-Tyr-DCit-Leu-Arg-Pro-DAla-NH₂; [Ac-D-2-Nal1, D-4-Cpa2, D-3-Pal3, Arg5, D-Cit6, D-Ala10]GnRH; GnRH Antagonist Acyline; N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(carbamimidoyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide
EINECS	Contact for details

Quality Control

Our Acyline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Acetate Content (HPLC)	5 - 15%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.