Description

5,7-Difluoro-B-(S)-Aminotetraline is a chiral, fluorinated aminotetraline derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated pharmaceutical intermediate and chiral building block for the development of active pharmaceutical ingredients (APIs) and bioactive molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where its unique stereochemistry and fluorine substitution pattern enable the creation of novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of central nervous system (CNS) active drugs, dopamine receptor ligands, and other neurologically targeted APIs.
• Chiral Building Block: Used in asymmetric synthesis to introduce the (S)-configured aminotetraline scaffold into complex molecular architectures.
• Agrochemical Research: Serves as a starting material for developing novel fluorinated compounds with potential herbicidal or pesticidal activity.
• Chemical Biology Probe: Utilized in medicinal chemistry research to study structure-activity relationships (SAR) and receptor binding profiles.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of fluorinated fine chemicals.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5,7-Difluoro-B-(S)-Aminotetraline
CAS No.	170151-28-7
Molecular Formula	C₁₀H₁₁F₂N
Molecular Weight	183.20 g/mol
Synonyms	(1S)-5,7-Difluoro-1,2,3,4-tetrahydro-1-naphthalenamine; (S)-5,7-Difluoro-1,2,3,4-tetrahydro-1-naphthylamine; (S)-5,7-Difluoro-α-tetralinamine; B-(S)-Amino-5,7-difluorotetralin; 5,7-Difluoro-(S)-1-amino-1,2,3,4-tetrahydronaphthalene; (1S)-5,7-Difluoro-1,2,3,4-tetrahydronaphthalen-1-amine; (S)-1-Amino-5,7-difluoro-1,2,3,4-tetrahydronaphthalene
EINECS	Contact for details

Quality Control

Our 5,7-Difluoro-B-(S)-Aminotetraline is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.