Description

Nepicastat Hydrochloride CAS NO 170151-24-3 is a potent and selective inhibitor of dopamine β-hydroxylase (DBH), an enzyme crucial in the catecholamine biosynthesis pathway. This pharmacological profile makes it a valuable research chemical for investigating cardiovascular and neurological disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) focused on developing novel therapeutic agents.

Application

• Pharmacological Research: Used as a reference standard and active compound in studies targeting dopamine β-hydroxylase (DBH) inhibition.
• Cardiovascular Disease Models: Investigated in preclinical research for conditions like hypertension and heart failure due to its effect on norepinephrine levels.
• Neuropsychiatric Disorder Studies: Applied in research models for addiction, stress-related disorders, and Parkinson's disease.
• Biochemical Assay Development: Serves as a key component in enzymatic assays to screen for new DBH inhibitors.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical substances.
• Preclinical Drug Development: Employed in early-stage drug discovery programs to explore the therapeutic potential of DBH modulation.

Basic Information

Product Name	Nepicastat Hydrochloride
CAS No.	170151-24-3
Molecular Formula	C₁₆H₂₀N₂O₂ • HCl
Molecular Weight	308.80 g/mol
Synonyms	RS-25560-197; (R)-5-(Aminomethyl)-1-(6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)-1,3-dihydro-2H-imidazol-2-one hydrochloride; Nepicastat HCl; Dopamine β-Hydroxylase Inhibitor; DBH Inhibitor RS-25560
EINECS	Contact for details

Quality Control

Our Nepicastat Hydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our commitment to supplying reliable and well-characterized research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.