Description

2-((2-Chloropyrimidin-5-yl)oxy)acetonitrile is a versatile and high-value pyrimidine-based building block, essential for advanced organic synthesis. Its molecular structure, featuring both a chloropyrimidine ring and a reactive nitrile group, makes it a critical intermediate for constructing complex heterocyclic compounds. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactive pyrimidine scaffold.
• Material Science: Serves as a precursor for functionalized polymers and advanced organic materials with specific electronic properties.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex functionalities.
• Academic & Contract Research: A valuable reagent for methodological studies and library synthesis in academic and contract research organizations (CROs).

Basic Information

Product Name	2-((2-Chloropyrimidin-5-yl)oxy)acetonitrile
CAS No.	169677-65-0
Molecular Formula	C6H4ClN3O
Molecular Weight	169.57 g/mol
Synonyms	5-(Cyanomethoxy)-2-chloropyrimidine; Acetonitrile, [(2-chloro-5-pyrimidinyl)oxy]-; 2-Chloro-5-(cyanomethoxy)pyrimidine; [(2-Chloropyrimidin-5-yl)oxy]acetonitrile; 2-Chloropyrimidin-5-yloxyacetonitrile; 169677-65-0; (2-Chloro-pyrimidin-5-yloxy)-acetonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-((2-Chloropyrimidin-5-yl)oxy)acetonitrile is produced and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment. Our quality system is designed to support cGMP and ISO standards for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.