Description

n-[2-(Fmoc-Amino)-Ethyl]Glycine tert-Butyl Ester Hydrochloride is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is specifically engineered to provide superior stability and controlled reactivity during solid-phase and solution-phase peptide coupling, ensuring high yields and minimal side reactions. It is a critical building block for researchers and manufacturers in pharmaceutical development, proteomics, and the production of complex peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the controlled assembly of complex peptide sequences.
• Non-Natural Amino Acid Incorporation: Used to introduce glycine derivatives with specific side-chain functionalities into peptides to alter their biological activity or stability.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of peptide drugs, hormones, and enzyme inhibitors.
• Bioconjugation and Labeling: The reactive amino and carboxyl groups, when appropriately deprotected, facilitate site-specific conjugation with dyes, tags, or other biomolecules.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Industrial Research: A fundamental reagent for studying peptide structure-function relationships and developing novel synthetic methodologies.

Basic Information

Product Name	n-[2-(Fmoc-Amino)-Ethyl]Glycine tert-Butyl Ester Hydrochloride
CAS No.	169396-88-7
Molecular Formula	C24H30N2O5 • HCl
Molecular Weight	471.0 g/mol (monoisotopic)
Synonyms	Fmoc-N-(2-Aminoethyl)glycine-OtBu hydrochloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-(2-{[2-(tert-butoxy)-2-oxoethyl]amino}ethyl)ethane-1,2-diamine hydrochloride; Nα-Fmoc-Nβ-(2-aminoethyl)glycine tert-butyl ester hydrochloride; Fmoc-Aee-OH-OtBu • HCl; (2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}ethylamino)acetic acid tert-butyl ester hydrochloride; Fmoc-Lys(Alloc)-OH related derivative; Protected amino acid ester hydrochloride
EINECS	Contact for details

Quality Control

Every batch of n-[2-(Fmoc-Amino)-Ethyl]Glycine tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.