Description

H-Leu-Ser-Ala-Leu-Oh is a synthetic tetrapeptide sequence composed of Leucine, Serine, Alanine, and Leucine residues with a free C-terminal carboxylic acid. This compound is a crucial building block in peptide synthesis and pharmaceutical research, offering a defined sequence for studying structure-activity relationships and developing novel bioactive molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for drug discovery, proteomics, and as a reference standard.

Application

• Pharmaceutical Intermediate: Serves as a key fragment in the solid-phase or solution-phase synthesis of larger, more complex therapeutic peptides.
• Biochemical Research: Used as a model substrate or inhibitor in enzymatic studies to investigate protease specificity and function.
• Drug Discovery: Acts as a core structural motif for screening and developing new peptide-based drugs targeting various diseases.
• Reference Standard: Employed in analytical laboratories for method development, calibration, and quality control of peptide-related products.
• Proteomics & Peptidomics: Utilized in mass spectrometry studies as a calibrant or to understand peptide fragmentation patterns.

Basic Information

Product Name	H-Leu-Ser-Ala-Leu-Oh
CAS No.	169249-03-0
Molecular Formula	C20H36N4O7
Molecular Weight	444.52 g/mol
Synonyms	L-Leucyl-L-seryl-L-alanyl-L-leucine; Leu-Ser-Ala-Leu; LSAL; Tetrapeptide Leu-Ser-Ala-Leu; H-Leu-Ser-Ala-Leu-OH; NSC 760421; (S)-2-((S)-2-((S)-2-((S)-2-Amino-4-methylpentanamido)-3-hydroxypropanamido)propanamido)-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Every batch of H-Leu-Ser-Ala-Leu-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide full traceability and guarantee high purity suitable for research and development applications. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC), and other critical parameters is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept under inert atmosphere or desiccated upon opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.