Description

(His32,Leu34)-Neuropeptide Y (32-36) is a synthetic peptide fragment derived from the C-terminal region of Neuropeptide Y (NPY), a critical neuromodulator involved in numerous physiological processes. This specific analog, featuring histidine and leucine substitutions, is a vital research tool for studying NPY receptor interactions, signal transduction, and structure-activity relationships. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, metabolic disorder research, and drug discovery programs targeting the NPY receptor family.

Application

• Neuroscience Research: Investigation of Neuropeptide Y (NPY) receptor binding affinity, subtype selectivity (Y1, Y2, Y4, Y5, Y6), and downstream signaling pathways.
• Drug Discovery & Development: Serving as a reference standard, competitive ligand, or lead compound in the design of novel NPY receptor agonists or antagonists for treating obesity, anxiety, and cardiovascular diseases.
• Structure-Activity Relationship (SAR) Studies: Elucidating the role of specific amino acid residues (His32, Leu34) in the biological activity and receptor interaction of NPY fragments.
• Biochemical Assays: Use in competitive binding assays (e.g., radioimmunoassays, fluorescence polarization) to characterize receptor-ligand interactions and screen compound libraries.
• Metabolic Research: Studying the effects of NPY analogs on appetite regulation, energy homeostasis, and insulin secretion.
• Academic & Pharmaceutical R&D: A key reagent for basic research and preclinical studies focused on the central and peripheral nervous systems.

Basic Information

Product Name	(His32,Leu34)-Neuropeptide Y (32-36)
CAS No.	168916-68-5
Molecular Formula	C31H51N11O8
Molecular Weight	705.82 g/mol
Synonyms	NPY (32-36), [His32, Leu34]-Neuropeptide Y (32-36); H-His-Leu-Arg-His-Tyr-OH; Neuropeptide Y fragment 32-36 analog; [His32,Leu34]NPY(32-36); NPY (32-36) amide analog; Tyr-Arg-Leu-Arg-His-NH2 analog; NPY C-terminal pentapeptide analog
EINECS	Contact for details

Quality Control

Every batch of (His32,Leu34)-Neuropeptide Y (32-36) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with standards applicable to research-grade peptides. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for purity (HPLC), molecular weight confirmation (MS), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Molecular Weight	705.82 ± 2 Da (by MS)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC/IC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.