Description

Fmoc-D-Cys(Acm)-Oh CAS NO 168300-88-7 is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for researchers and manufacturers developing complex peptides with specific stereochemistry and disulfide bridge formation capabilities. It is primarily used by pharmaceutical R&D teams, biotechnology companies, and CROs focused on novel therapeutic peptide discovery and production.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the controlled assembly of peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel therapeutic peptides targeting various diseases.
• Disulfide Bridge Formation: The Acm (acetamidomethyl) protecting group allows for the orthogonal formation of intramolecular disulfide bonds, crucial for the bioactivity of many peptides.
• Non-Natural Peptide Libraries: Enables the incorporation of D-configuration cysteine analogs to create peptides with enhanced metabolic stability and novel properties.
• Bioconjugation and Protein Engineering: Serves as a precursor for site-specific labeling or modification of proteins and biomolecules.
• Contract Manufacturing (CMO): A critical raw material for the GMP-compliant production of peptide-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-D-Cys(Acm)-Oh
CAS No.	168300-88-7
Molecular Formula	C₂₁H₂₂N₂O₅S
Molecular Weight	414.48 g/mol
Synonyms	Fmoc-D-Cys(Acm)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[(acetamido)methyl]-D-cysteine; Fmoc-D-Cysteine(Acm)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((acetamidomethyl)thio)propanoic acid; Fmoc-D-Cys(Acetamidomethyl)-OH; N-α-Fmoc-S-acetamidomethyl-D-cysteine; Fmoc-D-Cysteine(Acetamidomethyl)-OH; Fmoc-D-Cys(Acm)
EINECS	Contact for details

Quality Control

Our Fmoc-D-Cys(Acm)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Optical Rotation	-20.0° to -24.0° (c=1, DMF)
Water Content (KF)	≤0.5%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.