Description

2-Iodo-L-Phenylalanine,Hydrochloride is a halogenated derivative of the essential amino acid L-phenylalanine, modified with an iodine atom at the 2-position of the aromatic ring and presented as a hydrochloride salt. This specific structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive compounds. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, peptide synthesis, and the development of radiopharmaceuticals or molecular imaging agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting neurological disorders or requiring iodine for molecular labeling.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate iodinated phenylalanine residues, which can be crucial for structure-activity relationship (SAR) studies or creating peptide-based radiopharmaceuticals.
• Medicinal Chemistry Research: Serves as a building block for creating compound libraries to explore new chemical entities in drug discovery programs.
• Biochemical Research: Employed in studies of enzyme mechanisms, metabolic pathways, or as a substrate analog in biochemical assays.
• Radiopharmaceutical Precursor: The iodine atom provides a potential site for radioiodination (e.g., with I-123, I-125, I-131), making it a precursor for diagnostic or therapeutic radiopharmaceuticals.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in asymmetric catalytic reactions due to its inherent chirality.

Basic Information

Product Name	2-Iodo-L-Phenylalanine,Hydrochloride
CAS No.	167817-57-4
Molecular Formula	C9H11INO2 • HCl
Molecular Weight	329.56 g/mol
Synonyms	(S)-2-Amino-3-(2-iodophenyl)propanoic acid hydrochloride; L-2-Iodophenylalanine hydrochloride; 2-Iodo-L-phenylalanine HCl; (2S)-2-Azaniumyl-3-(2-iodophenyl)propanoate chloride; 2-Iodo-L-Phe-OH • HCl; 2-Iodo-L-α-aminohydrocinnamic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Iodo-L-Phenylalanine,Hydrochloride is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity. Each batch is analyzed using advanced techniques including HPLC, NMR, and optical rotation measurement to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in research and development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.