Description

4-Amino-3-Trifluoromethyl-Benzoic Acid Methyl Ester is a high-value trifluoromethylated aniline derivative and a key pharmaceutical intermediate. This compound is prized for its role in introducing the metabolically stable trifluoromethyl group into target molecules, which can significantly enhance their biological activity and pharmacokinetic properties. It is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and anticancer therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves compound efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs), contributing to improved material performance.
• Advanced Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands for catalysis, and functional materials with tailored properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and contract research organizations (CROs/CMOs) developing proprietary compounds for clients.

Basic Information

Product Name	4-Amino-3-Trifluoromethyl-Benzoic Acid Methyl Ester
CAS No.	167760-75-0
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	Methyl 4-Amino-3-(trifluoromethyl)benzoate; Benzoic acid, 4-amino-3-(trifluoromethyl)-, methyl ester; 4-Amino-α,α,α-trifluoro-m-toluic acid methyl ester; Methyl 4-amino-α,α,α-trifluoro-m-toluate; 3-Trifluoromethyl-4-aminobenzoic acid methyl ester; 4-Amino-3-trifluoromethylbenzoic acid methyl ester; 4-Amino-3-CF3-benzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Trifluoromethyl-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.