Description

L-4-Cyanophenylalanine is a non-natural, side-chain modified amino acid derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring a cyano group on the phenyl ring, makes it an invaluable tool for probing protein structure and function, as well as for creating novel peptide-based materials. This high-purity compound is essential for researchers and manufacturers in the fields of pharmaceutical development, biochemical research, and advanced material science.

Application

• Pharmaceutical Research & Development: Used as a site-specific infrared probe or spectroscopic label in proteins for studying folding, dynamics, and interactions via FTIR spectroscopy.
• Peptide Synthesis: Acts as a key unnatural amino acid building block in Solid-Phase Peptide Synthesis (SPPS) for creating peptides with novel properties.
• Chemical Biology: Employed in the synthesis of activity-based probes (ABPs) and photoaffinity labels to investigate enzyme mechanisms and identify drug targets.
• Bioconjugation: The cyano group can serve as a chemical handle for bioorthogonal conjugation reactions, enabling the attachment of fluorophores, drugs, or other functional molecules to peptides and proteins.
• Material Science: Incorporated into synthetic polymers or bio-hybrid materials to impart specific electronic or self-assembly properties derived from its aromatic and polar side chain.
• Academic Research: A fundamental reagent for studying amino acid metabolism, protein engineering, and the development of novel biosensors.

Basic Information

Product Name	L-4-Cyanophenylalanine
CAS No.	167479-78-9
Molecular Formula	C10H10N2O2
Molecular Weight	190.20 g/mol
Synonyms	L-p-Cyanophenylalanine; (2S)-2-Amino-3-(4-cyanophenyl)propanoic acid; 4-Cyano-L-phenylalanine; L-4-CN-Phe; F4CN; p-Cyano-L-phenylalanine; L-4-Cyanophenyl alanine; 4-Cyanophenylalanine, L- isomer
EINECS	Contact for details

Quality Control

Our L-4-Cyanophenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for research and pharmaceutical applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.