Description

Benzamide, n-(4-Amino-1,2,3,6-Tetrahydro-1-Methyl-2,6-Dioxo-5-Pyrimidinyl)-4-(trifluoromethyl)- is a specialized heterocyclic compound featuring a benzamide core fused with a modified uracil (pyrimidinedione) ring system and a trifluoromethyl substituent. This unique molecular architecture makes it a critical intermediate in advanced pharmaceutical research and development, particularly for creating novel therapeutic agents. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural moiety in the research and process development of new APIs.
• Biochemical Research: Used as a reference standard or probe compound in enzymatic and receptor binding studies due to its specific heterocyclic structure.
• Agrochemical Research: Potential intermediate in the development of advanced pesticides and herbicides, leveraging the biological activity of the pyrimidinedione scaffold.
• Material Science Precursor: Can be utilized in the synthesis of specialized polymers or ligands for catalytic systems where fluorine-containing groups are advantageous.

Basic Information

Product Name	Benzamide, n-(4-Amino-1,2,3,6-Tetrahydro-1-Methyl-2,6-Dioxo-5-Pyrimidinyl)-4-(trifluoromethyl)-
CAS No.	167299-07-2
Molecular Formula	C13H11F3N4O3
Molecular Weight	328.25 g/mol
Synonyms	4-(Trifluoromethyl)-N-[4-amino-1-methyl-2,6-dioxo-1,2,3,6-tetrahydro-5-pyrimidinyl]benzamide; 1-Methyl-5-[[[4-(trifluoromethyl)phenyl]carbonyl]amino]-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-[[[4-(Trifluoromethyl)benzoyl]amino]-1-methylbarbituric acid; 1-Methyl-5-[(4-trifluoromethylbenzoyl)amino]barbituric acid; N-(4-Amino-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-5-yl)-4-(trifluoromethyl)benzamide
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliable supply for your research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.