Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-(Difluoromethoxy)-6-Fluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-, Monohydrochloride, (S)- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial interest due to its role as a key building block in the synthesis of novel antibacterial agents, particularly fluoroquinolone antibiotics. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities engaged in the development and production of next-generation antimicrobial therapies.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Critical synthetic precursor in the manufacture of advanced fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new antibacterial compounds.
• Process Chemistry & Scale-Up: Serves as a benchmark material for optimizing synthetic routes and scaling production from laboratory to commercial batch sizes.
• Reference Standard: Employed as a high-purity analytical standard for quality control (QC) and regulatory submissions in pharmaceutical manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of proprietary drug substances.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-8-(Difluoromethoxy)-6-Fluoro-1,4-Dihydro-7-(3-Methyl-1-Piperazinyl)-4-Oxo-, Monohydrochloride, (S)-
CAS No.	167290-54-2
Molecular Formula	C19H21F3N3O4 • HCl
Molecular Weight	463.85 g/mol (Free base: 427.39 g/mol)
Synonyms	(S)-1-Cyclopropyl-8-(difluoromethoxy)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Monohydrochloride; (S)-Ofloxacin Intermediate; (S)-Ofloxacin Impurity; Levofloxacin Related Compound; (S)-(-)-Ofloxacin Hydrochloride; DR-3355; (3S)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic Acid Hydrochloride (related structure)
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, residual solvent analysis, and identification by IR and MS, to ensure it meets stringent specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed-upon standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if necessary and opened only in a moisture-controlled environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (Anhydrous basis)
Chiral Purity (HPLC)	≥ 99.0% (S)-enantiomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.