Description

Autocamtide-2-Related Inhibitory Peptide is a potent and selective cell-permeable inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). This compound matters for researchers as it provides a critical tool for dissecting the specific roles of CaMKII in cellular signaling pathways, particularly in neuroscience and cardiology. It is essential for pharmaceutical R&D teams, academic laboratories, and biotechnology companies focused on neurological disorders, cardiac function, and intracellular calcium signaling mechanisms.

Application

• Biochemical Research: Used as a specific inhibitor to study CaMKII activity in cell-free enzymatic assays and signal transduction studies.
• Neuroscience Studies: Critical for investigating the role of CaMKII in synaptic plasticity, learning, memory, and models of neurological diseases.
• Cardiovascular Research: Applied in studies of cardiac myocyte function, arrhythmias, and hypertrophy where CaMKII signaling is a key pathway.
• Cell Biology: Utilized in cell culture experiments to inhibit CaMKII and observe downstream effects on gene expression, cell cycle, and apoptosis.
• Drug Discovery: Serves as a reference compound and pharmacological tool in high-throughput screening and target validation for CaMKII-related therapeutics.
• Diagnostic Development: Potential use in the development of assays to measure CaMKII activity in clinical or research samples.

Basic Information

Product Name	Autocamtide-2-Related Inhibitory Peptide
CAS No.	167114-91-2
Molecular Formula	C₂₀H₃₇N₉O₈
Molecular Weight	531.6 g/mol
Synonyms	Autocamtide-2-Related Inhibitory Peptide; AIP; CaMKII Inhibitor Peptide; CaMKII(281-309); Autocamtide-2-related Inhibitory Peptide; Myristoylated AIP; m-AIP; CaM Kinase II Inhibitor (281-309)
EINECS	Contact for details

Quality Control

Our Autocamtide-2-Related Inhibitory Peptide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity determination and mass spectrometry for identity confirmation, to ensure it meets the high standards required for critical research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.