Description

n-Fmoc-S-Trityl-D-Cysteine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is specifically engineered to provide orthogonal protection for both the amino and thiol groups of D-cysteine, enabling precise, sequential deprotection strategies in complex solid-phase and solution-phase peptide assembly. It is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostic agents, and biochemical tools where the stereochemical integrity and controlled reactivity of cysteine are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the controlled incorporation of D-cysteine residues using Fmoc-chemistry protocols.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex cyclic peptides, peptide conjugates, and small protein fragments requiring specific disulfide bond patterning.
• Pharmaceutical Intermediate: Serves as a chiral building block in the research and development of novel peptide drugs, including hormone analogs, antimicrobial peptides, and targeted cancer therapies.
• Bioconjugation and Labeling: The protected thiol group allows for site-specific modification of peptides with fluorophores, biotin, polymers, or other functional moieties after selective deprotection.
• Chemical Biology Probes: Integral for creating peptide-based inhibitors, activity-based probes, and tools to study enzyme mechanisms and protein-protein interactions.
• Material Science: Used in the synthesis of peptide-derived polymers and biomaterials where cysteine residues are needed for cross-linking or imparting specific functional properties.

Basic Information

Product Name	n-Fmoc-S-Trityl-D-Cysteine
CAS No.	167015-11-4
Molecular Formula	C37H31NO4S
Molecular Weight	585.71 g/mol
Synonyms	Fmoc-D-Cys(Trt)-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tritylthio)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-trityl-D-cysteine; D-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-; Fmoc-Cys(Trt)-D-OH; Fmoc-D-Cysteine(S-Trityl)-OH; N-α-Fmoc-S-trityl-D-cysteine
EINECS	Contact for details

Quality Control

Our n-Fmoc-S-Trityl-D-Cysteine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate production, with specifications tailored to meet the rigorous demands of GMP-compliant peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Specific range provided per COA
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Single Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.