Description

1-Methyl-2-Oxo-5-Indolinesulfonyl Chloride is a specialized sulfonyl chloride derivative of the indoline scaffold, serving as a critical building block in advanced organic synthesis. Its primary value lies in its high reactivity as a sulfonylation reagent, enabling the efficient introduction of the sulfonyl functional group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides.
• Chemical Biology Probes: Employed in the creation of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Material Science: Building block for advanced polymers and functional materials with specific sulfonamide linkages.
• Organic Synthesis Reagent: Acts as a versatile sulfonylation agent for amines and alcohols in complex multi-step syntheses.

Basic Information

Product Name	1-Methyl-2-Oxo-5-Indolinesulfonyl Chloride
CAS No.	166883-20-1
Molecular Formula	C9H8ClNO3S
Molecular Weight	245.68 g/mol
Synonyms	5-(Chlorosulfonyl)-1-methylindolin-2-one; 1-Methyl-2-oxoindoline-5-sulfonyl chloride; 1-Methylisatin-5-sulfonyl chloride; 5-(Chlorosulfonyl)-1-methyl-2-indolinone; 1-Methyl-2-indolinone-5-sulfonyl chloride; 1-Methyl-2-oxindole-5-sulfonyl chloride; 166883-20-1; 5-Sulfonyl chloride-1-methyl-2-oxindole
EINECS	Contact for details

Quality Control

Our 1-Methyl-2-Oxo-5-Indolinesulfonyl Chloride is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.