Description

Fmoc-(Fmochmb)Lys(Boc)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in enabling the complex, multi-step synthesis of challenging peptides, particularly those requiring selective deprotection strategies. Pharmaceutical researchers and fine chemical manufacturers need it for the development of therapeutic peptides, peptidomimetics, and biochemical probes where precise sequence control is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block for the incorporation of lysine residues with orthogonal side-chain protection, facilitating complex peptide assembly.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Peptidomimetic Design: Essential for creating modified peptide structures with enhanced stability, bioavailability, or receptor affinity.
• Bioconjugation and Linker Chemistry: The protected lysine side chain provides a handle for site-specific attachment of labels, tags, or payloads.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic and Industrial Research: A vital reagent for biochemical and structural biology studies investigating protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	Fmoc-(Fmochmb)Lys(Boc)-Oh
CAS No.	166881-56-7
Molecular Formula	C₄₃H₄₇N₃O₉
Molecular Weight	749.86 g/mol
Synonyms	Fmoc-Lys(Fmochmb)-Boc; Nα-Fmoc-Nε-[(9-fluorenylmethoxycarbonyl)aminomethylbenzyloxycarbonyl]-Nε-tert-butoxycarbonyl-L-lysine; Fmoc-Lys(Fmoc-Hmb)-Boc-OH; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-[[[(9H-fluoren-9-yl)methoxy]carbonyl]amino]methyl]benzyloxycarbonyl]-Nε-(tert-butoxycarbonyl)-L-lysine; Fmoc-Lys(Fmoc-Hmb)-OtBu; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((((((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)benzyl)oxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(Fmochmb)Lys(Boc)-Oh is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive peptide synthesis. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and optical rotation verification. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.