Description

Fmoc-(Dmb)Gly-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for enabling complex peptide chain assembly by providing selective deprotection strategies, which is essential for synthesizing challenging sequences and modified peptides. It is a fundamental building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic tools, and biochemical probes. Its precise structure ensures high coupling efficiency and purity in automated synthesis platforms.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the construction of complex and long-chain peptides.
• Pharmaceutical Research & Development: Used in the discovery and production of novel peptide-based therapeutics, including hormones, antibiotics, and targeted drug conjugates.
• Bioconjugation and Probe Synthesis: Serves as a precursor for creating labeled peptides, affinity tags, and molecular imaging agents for diagnostic applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive peptide leads.
• Academic & Industrial Research: Essential for biochemical studies investigating protein-protein interactions, enzyme substrates, and structure-activity relationships (SAR).
• Custom Peptide Service Providers: A critical raw material for CROs and CDMOs offering bespoke peptide synthesis services to global clients.

Basic Information

Product Name	Fmoc-(Dmb)Gly-Oh
CAS No.	166881-42-1
Molecular Formula	C₂₈H₂₉NO₆
Molecular Weight	475.53 g/mol
Synonyms	Fmoc-(2,4-dimethoxybenzyl)glycine; N-(9-Fluorenylmethoxycarbonyl)-N-(2,4-dimethoxybenzyl)glycine; Fmoc-Dmb-Gly-OH; N-Fmoc-N-(2,4-dimethoxybenzyl)glycine; (9H-Fluoren-9-yl)methyl N-[(2,4-dimethoxyphenyl)methyl]carbamoyl]glycinate; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-[(2,4-dimethoxyphenyl)methyl]-; Fmoc-N-(Dmb)-Gly-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(Dmb)Gly-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring compliance with research and cGMP-grade material requirements for preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and performance. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.