Description

(2R,4R)-4-Methylglutamic Acid Hydrochloride is a high-purity, stereochemically defined amino acid derivative. This compound is a critical chiral building block and intermediate in the research and development of novel pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, peptide synthesis, and the development of metabolic modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in metabolic and neurological disorder research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and as a scaffold for designing enzyme inhibitors or receptor modulators.
• Peptide Synthesis: Serves as a protected, non-proteinogenic amino acid building block for the preparation of specialized peptides with enhanced stability or biological activity.
• Biochemical Research: Employed as a standard or reagent in studies of glutamate receptor pharmacology and amino acid metabolism pathways.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric synthesis due to its defined stereocenters.

Basic Information

Product Name	(2R,4R)-4-Methylglutamic Acid Hydrochloride
CAS No.	166756-77-0
Molecular Formula	C6H11NO4 • HCl
Molecular Weight	197.62 g/mol (Free base: 161.16)
Synonyms	(2R,4R)-4-Methyl-L-glutamic Acid Hydrochloride; (2R,4R)-4-Methylglutamic Acid HCl; (2R,4R)-4-Me-Glu-OH • HCl; 4-Methyl-DL-glutamic Acid Hydrochloride (stereoisomer mixture); (2R,4R)-2-Amino-4-methylpentanedioic Acid Hydrochloride; 4-Methyl-L-glutamic Acid Hydrochloride (stereoisomer); 4-Methylglutamate Hydrochloride
EINECS	Contact for details

Quality Control

Our (2R,4R)-4-Methylglutamic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.