Description

2-Chloro-5-Cyclopropylpyrimidine is a high-purity halogenated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its molecular architecture, featuring a reactive chloro substituent and a cyclopropyl ring, makes it an indispensable intermediate for constructing complex pharmacologically active molecules. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Development: Used as a precursor in creating advanced herbicides, fungicides, and pesticides with novel modes of action.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and liquid crystals.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the cyclopropylpyrimidine moiety into more complex structures.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and process development projects.

Basic Information

Product Name	2-Chloro-5-Cyclopropylpyrimidine
CAS No.	166740-44-9
Molecular Formula	C7H7ClN2
Molecular Weight	154.60 g/mol
Synonyms	5-Cyclopropyl-2-chloropyrimidine; 2-Chloro-5-cyclopropyl-pyrimidine; Pyrimidine, 2-chloro-5-cyclopropyl-; 2-Chlorocyclopropylpyrimidine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Cyclopropylpyrimidine is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.