Description

H-L-Cys(Trt)-Nh2 Hcl is a protected cysteine derivative, specifically the hydrochloride salt of S-trityl-L-cysteine amide. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it provides a stable, orthogonal protecting group strategy for the thiol functionality. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of cysteine residues into peptide chains.
• Pharmaceutical Research: Used in the development of peptide drugs, hormones, and enzyme inhibitors where disulfide bridge formation is crucial for bioactivity.
• Bioconjugation: Serves as a precursor for creating thiol-reactive probes, linkers, and tags for labeling proteins and antibodies.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships (SAR) involving cysteine.
• Protecting Group Chemistry: The trityl (Trt) group offers acid-labile protection, allowing for selective deprotection in multi-step syntheses.

Basic Information

Product Name	H-L-Cys(Trt)-Nh2 Hcl
CAS No.	166737-85-5
Molecular Formula	C22H23ClN2OS
Molecular Weight	398.94 g/mol
Synonyms	S-Trityl-L-cysteine amide hydrochloride; L-Cysteine, S-(triphenylmethyl)-, amide, hydrochloride; Fmoc-Cys(Trt)-NH2·HCl (precursor); H-Cys(Trt)-NH2·HCl; Cysteine amide Trt-protected HCl salt; S-Trityl-L-cysteinamide hydrochloride; (R)-2-Amino-3-((tritylthio)propanamide hydrochloride
EINECS	Contact for details

Quality Control

Our H-L-Cys(Trt)-Nh2 Hcl is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.