Description

(S)-Potassium Warfarin is the potassium salt of the (S)-enantiomer of the widely used anticoagulant, warfarin. This specific stereoisomer is of significant interest in pharmaceutical research and development due to its distinct biological activity and metabolic profile compared to the racemic mixture. It is a critical intermediate and reference standard for the synthesis and analytical characterization of enantiomerically pure anticoagulant agents. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical industry focusing on cardiovascular drugs, chiral separations, and metabolic studies.

Application

• Pharmaceutical Reference Standard: Used as a primary standard in HPLC, LC-MS, and other analytical methods for the quantification and qualification of warfarin enantiomers.
• Chiral Intermediate: Serves as a key building block in the synthesis of enantiomerically pure anticoagulant pharmaceuticals and novel drug candidates.
• Metabolic and Pharmacokinetic Studies: Employed in research to investigate the distinct absorption, distribution, metabolism, and excretion (ADME) properties of the (S)-warfarin enantiomer.
• Biochemical Research: Utilized in enzyme inhibition assays and studies targeting vitamin K epoxide reductase (VKOR) and other relevant biological pathways.
• Quality Control: Acts as a critical quality control material for manufacturers producing single-enantiomer anticoagulant medications.

Basic Information

Product Name	(S)-Potassium Warfarin
CAS No.	166320-53-2
Molecular Formula	C19H15KO4
Molecular Weight	346.42 g/mol
Synonyms	(S)-Warfarin Potassium Salt; Potassium (S)-Warfarin; (S)-3-(α-Acetonylbenzyl)-4-hydroxycoumarin Potassium Salt; Coumadin (S)-Enantiomer Potassium Salt; (S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one Potassium Salt; Marevan (S)-Enantiomer Potassium Salt; (S)-Warfarin K Salt
EINECS	Contact for details

Quality Control

Our (S)-Potassium Warfarin is manufactured under strict quality systems to ensure high chemical and enantiomeric purity suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric excess, and impurity profiles. We support compliance with cGMP guidelines for API intermediates where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (HPLC)	≥99.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.