Description

(R)-Potassium Warfarin is the potassium salt of the (R)-enantiomer of the anticoagulant agent warfarin. This specific stereoisomer is a critical reference standard and intermediate in pharmaceutical research and development, particularly for studying stereoselective metabolism and activity. It is essential for analytical laboratories, regulatory bodies, and pharmaceutical companies engaged in the development, quality control, and bioequivalence studies of anticoagulant therapies. The product is supplied with full traceability and documentation to support rigorous scientific and regulatory requirements.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the identification, assay, and impurity profiling of warfarin sodium in pharmacopeial testing (USP, EP).
• Metabolic and Pharmacokinetic Research: Serves as a key material for in vitro and in vivo studies investigating the stereoselective metabolism, distribution, and clearance of warfarin enantiomers.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the controlled synthesis and purification of stereochemically defined anticoagulant drug substances.
• Analytical Method Development: Critical for developing and validating chiral separation methods, such as chiral HPLC or CE, for enantiomeric purity determination.
• Regulatory Compliance and Documentation: Provides essential material for generating data for regulatory submissions (e.g., FDA, EMA) requiring enantiomer-specific information.
• Biochemical Assay Development: Used in studies targeting vitamin K epoxide reductase (VKOR) and other enzymes to understand the mechanistic differences between warfarin isomers.

Basic Information

Product Name	(R)-Potassium Warfarin
CAS No.	166320-52-1
Molecular Formula	C19H15KO4
Molecular Weight	346.42 g/mol
Synonyms	(R)-Warfarin Potassium Salt; Potassium (R)-Warfarin; (R)-3-(α-Acetonylbenzyl)-4-hydroxycoumarin Potassium Salt; (2R)-2-[(1RS)-1-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-3-oxobutyl]benzoic Acid Potassium Salt; (R)-Coumadin Potassium; (R)-Marevan Potassium; (R)-Warfarin K+ Salt
EINECS	Contact for details

Quality Control

Every batch of (R)-Potassium Warfarin is manufactured under a quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and strength. Specifications are aligned with the requirements for high-purity pharmaceutical reference standards and intermediates. A Certificate of Analysis (COA) providing batch-specific data for chiral purity, assay, related substances, residual solvents, and other critical parameters is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0% (R)-isomer
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.