Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-[3-(Methylamino)-1-Piperidinyl]-4-Oxo- is a high-purity advanced pharmaceutical intermediate of significant commercial and research importance. This compound is a key structural motif in the synthesis of novel fluoroquinolone antibiotics, offering a critical building block for drug discovery and development. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in antimicrobial research and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of next-generation fluoroquinolone antibiotic candidates targeting resistant bacterial strains.
• Antimicrobial Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in medicinal chemistry to develop new antibacterial agents.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the final or penultimate steps of manufacturing complex antibiotic APIs under controlled GMP environments.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory testing of pharmaceutical products.
• Academic & Institutional Research: Utilized in university and institutional labs for biochemical studies on bacterial DNA gyrase and topoisomerase IV inhibition.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and process development services for clients in the pharmaceutical industry.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-8-Methoxy-7-[3-(Methylamino)-1-Piperidinyl]-4-Oxo-
CAS No.	165619-85-2
Molecular Formula	C20H25FN3O4
Molecular Weight	390.43 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid; 7-(3-Methylamino-1-piperidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; Gatifloxacin Intermediate; AM-1155 Intermediate; PD-135432 Intermediate; (3-Methylaminopiperidino) Quinolone Carboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities to meet pharmaceutical intermediate standards. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with customer specifications and regulatory expectations for advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.