Description

2-Chloro-4,5-Difluorobenzaldehyde is a versatile and highly functionalized aromatic aldehyde building block. Its value lies in the strategic positioning of chlorine and fluorine substituents, which are crucial for modulating the electronic and steric properties of target molecules in advanced synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, serving as a key intermediate for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro and chloro groups contribute to enhanced biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its ability to influence molecular polarity and packing.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or unique optical properties.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) and as a substrate for developing novel catalytic methodologies in academic and industrial R&D.
• Fluorinated Dye & Pigment Intermediate: Used in the synthesis of specialized dyes and pigments where fluorine atoms improve lightfastness and chemical stability.

Basic Information

Product Name	2-Chloro-4,5-Difluorobenzaldehyde
CAS No.	165047-23-4
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	2-Chloro-4,5-difluorobenzaldehyde; 4,5-Difluoro-2-chlorobenzaldehyde; Benzaldehyde, 2-chloro-4,5-difluoro-; 2-Chloro-4,5-difluorobenzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,5-Difluorobenzaldehyde is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.