Description

1-Propanone, 1-(2-Fluoro-3-Hydroxyphenyl)- is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining a propanone backbone with a fluorinated hydroxyphenyl group, which is crucial for modulating the physicochemical and biological properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atom enhances bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting applications.
• Complex Ligand & Catalyst Development: Employed in organometallic chemistry to create sophisticated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine-18 Radiochemistry: A potential precursor for the synthesis of Positron Emission Tomography (PET) imaging tracers, leveraging its fluorinated aromatic structure.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting fundamental research in synthetic methodology and fluorine chemistry.

Basic Information

Product Name	1-Propanone, 1-(2-Fluoro-3-Hydroxyphenyl)-
CAS No.	164072-22-4
Molecular Formula	C9H9FO2
Molecular Weight	168.16 g/mol
Synonyms	2'-Fluoro-3'-hydroxypropiophenone; 1-(2-Fluoro-3-hydroxyphenyl)propan-1-one; 3'-Hydroxy-2'-fluoropropiophenone; 2-Fluoro-3-hydroxypropiophenone; 1-Propanone,1-(2-fluoro-3-hydroxyphenyl)-; Propiophenone, 2'-fluoro-3'-hydroxy-; (2-Fluoro-3-hydroxyphenyl) ethyl ketone
EINECS	Contact for details

Quality Control

Our 1-Propanone, 1-(2-Fluoro-3-Hydroxyphenyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Consider storing under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.