Description

H-D-His(1-Me)-Oh is a modified, non-natural amino acid derivative featuring a methylated imidazole ring on the histidine side chain. This specific structural modification is critical for enhancing metabolic stability and fine-tuning biological activity in advanced peptide-based research and development. It serves as a key chiral building block for pharmaceutical chemists and biochemists working on novel therapeutic agents. Primary demand originates from the peptide synthesis sector, particularly for developing targeted drug candidates, enzyme inhibitors, and specialized biochemical probes.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the solid-phase and solution-phase synthesis of novel therapeutic peptides and peptidomimetics.
• Enzyme Inhibitor Design: Used to create analogs that interact with metalloenzymes or enzymes requiring histidine residues in their active sites, aiding in drug discovery.
• Biochemical Research: Employed in structure-activity relationship (SAR) studies to investigate the role of histidine methylation in protein function and ligand binding.
• Proteomics & Peptide Mapping: Serves as a specialty standard or labeled analog in mass spectrometry and analytical method development.
• API Development: Incorporated into the sequence of investigational new drugs (INDs) where enhanced stability or modified receptor affinity is required.

Basic Information

Item	Details
Product Name	H-D-His(1-Me)-Oh
CAS No.	163750-77-4
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	D-1-Methylhistidine; (R)-1-Methylhistidine; (2R)-2-Amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid; H-D-1-Me-His-OH; D-1-Methyl-L-histidine; Fmoc-D-1-methylhistidine (precursor); D-π-Methylhistidine
EINECS	Contact for details

Quality Control

Every batch of H-D-His(1-Me)-Oh is manufactured under strict quality management systems. We provide comprehensive analytical documentation to support your regulatory and R&D needs. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are supplied with each shipment. Our standard grade meets typical requirements for advanced pharmaceutical research, and we can support development with specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.