Description

H-D-His(3-Me)-Oh is a high-purity, non-natural amino acid derivative specifically engineered for advanced research and pharmaceutical development. This compound is a critical building block in the synthesis of novel peptides and peptidomimetics, offering enhanced stability and unique biological properties. It is essential for researchers and manufacturers in the fields of medicinal chemistry, peptide-based drug discovery, and biochemical research who require specialized, high-quality chiral intermediates.

Application

• Peptide Synthesis: A key chiral intermediate for solid-phase and solution-phase synthesis of modified peptides.
• Medicinal Chemistry Research: Used in the design and development of novel drug candidates, particularly for targeting specific receptors or enzymes.
• Bioconjugation: Serves as a modified linker or functional handle for creating peptide-protein or peptide-small molecule conjugates.
• Biochemical Probes: Incorporation into peptides to study structure-activity relationships (SAR) and protein-protein interactions.
• Pharmaceutical Intermediates: Production of active pharmaceutical ingredients (APIs) for potential therapeutic applications.
• Academic & Industrial R&D: Fundamental research in organic synthesis, peptide science, and chemical biology.

Basic Information

Product Name	H-D-His(3-Me)-Oh
CAS No.	163750-76-3
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	D-3-Methylhistidine; (R)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid; H-D-His(3-Me)-OH; D-3-Methyl-His-OH; D-π-Methylhistidine; (R)-3-(1-Methyl-1H-imidazol-4-yl)-2-aminopropanoic acid; D-1-Methylhistidine
EINECS	Contact for details

Quality Control

Our H-D-His(3-Me)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.