Description

Benzenamine, 2,3,4-Trifluoro-n-Hydroxy- (9Ci) is a specialized fluorinated aniline derivative, serving as a high-value building block in advanced organic synthesis. Its unique trifluoro-substituted aromatic structure with a hydroxylamine moiety makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce fluorine atoms and functional handles into target compounds, thereby modulating their bioactivity, metabolic stability, and physical characteristics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to develop advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance lipophilicity, membrane permeability, and environmental stability.
• Material Science Research: Building block for creating specialty polymers, liquid crystals, and organic electronic materials that benefit from fluorine's unique properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological mechanisms and diagnostic applications.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to form complex nitrogen-containing heterocycles.
• Fluorine Chemistry Development: A valuable reagent for academic and industrial research focused on expanding the toolbox of fluorination methodologies and understanding structure-activity relationships.

Basic Information

Product Name	Benzenamine, 2,3,4-Trifluoro-n-Hydroxy- (9Ci)
CAS No.	163734-02-9
Molecular Formula	C6H5F3N2O
Molecular Weight	178.11 g/mol
Synonyms	2,3,4-Trifluoro-N-hydroxyaniline; N-Hydroxy-2,3,4-trifluoroaniline; 2,3,4-Trifluorophenylhydroxylamine; (2,3,4-Trifluorophenyl)hydroxylamine; 2,3,4-Trifluoroaniline, N-hydroxy-; Hydroxylamine, N-(2,3,4-trifluorophenyl)-; Benzenamine, 2,3,4-trifluoro-N-hydroxy-
EINECS	Contact for details

Quality Control

Our Benzenamine, 2,3,4-Trifluoro-n-Hydroxy- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and regulatory compliance ensures a reliable supply for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.