Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[3-[(Ethylamino)Methyl]-1-Pyrrolidinyl]-6,8-Difluoro-1,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant commercial interest due to its role as a key synthetic precursor in the development of novel fluoroquinolone antibiotics. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of next-generation antibacterial agents, offering a critical building block for addressing antimicrobial resistance.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel fluoroquinolone antibiotic candidates.
• Antibacterial Drug Discovery: Used in medicinal chemistry research for structure-activity relationship (SAR) studies to develop new antibacterial agents.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key building block in the production of complex, high-value active pharmaceutical ingredients.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up projects under GMP conditions.
• Biochemical Research: Utilized in academic and industrial labs to study bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-[3-[(Ethylamino)Methyl]-1-Pyrrolidinyl]-6,8-Difluoro-1,4-Dihydro-4-Oxo-
CAS No.	163554-99-2
Molecular Formula	C20H23F2N3O3
Molecular Weight	391.41 g/mol
Synonyms	1-Cyclopropyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-((ethylamino)methyl)-1-pyrrolidinyl)-4-oxo-3-quinolinecarboxylic Acid; Gatifloxacin Intermediate; AM-1155 Intermediate; PD-135432 Intermediate; 6,8-Difluoro-1-cyclopropyl-7-(3-((ethylamino)methyl)-1-pyrrolidinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting customer specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to support regulatory filings. We operate under a quality management system aligned with GMP principles to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.