Description

Chlorotoxin CAS NO 163515-35-3 is a 36-amino acid peptide neurotoxin originally isolated from the venom of the deathstalker scorpion (*Leiurus quinquestriatus*). This compound is of significant interest due to its high selectivity for binding to chloride channels, particularly those associated with glioma and other neuroectodermal tumors. It serves as a critical research tool and a promising targeting agent in the development of novel diagnostic and therapeutic strategies for cancer. Key users include pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on oncology, neurobiology, and targeted drug delivery.

Application

• Cancer Research & Diagnostics: Used as a targeting moiety to specifically bind to and visualize glioma cells, aiding in tumor margin delineation and research.
• Targeted Drug Delivery Systems: Conjugated to nanoparticles, chemotherapeutic agents, or toxins to direct therapeutic payloads specifically to tumor cells, minimizing off-target effects.
• Molecular Imaging Probe Development: Labeled with fluorescent dyes or radionuclides (e.g., for PET/SPECT imaging) to create advanced imaging agents for preclinical and clinical studies.
• Ion Channel Studies: Serves as a specific ligand and inhibitor for studying the structure and function of chloride channels in neurological and cellular physiology research.
• Therapeutic Vaccine Development: Investigated as a component in vaccine strategies designed to elicit an immune response against chlorotoxin-expressing cancers.
• Biomarker Discovery: Employed in assays to identify and validate novel membrane proteins and biomarkers associated with chlorotoxin binding in various cancers.

Basic Information

Product Name	Chlorotoxin
CAS No.	163515-35-3
Molecular Formula	C164H253N47O49S7
Molecular Weight	~3994.8 g/mol
Synonyms	Chlorotoxin; TM-601; CTX; Glioma-specific peptide; Chloride channel blocker peptide; Leiurotoxin I (variant); Deathstalker scorpion toxin; CLTX; MRTX-101
EINECS	Contact for details

Quality Control

Our Chlorotoxin is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to relevant guidelines for peptide synthesis and can support development work requiring research-grade to GMP-grade materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. Aliquot into single-use vials to minimize freeze-thaw cycles and potential degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Biological Activity (Binding Assay)	Contact for details
Endotoxin Level (LAL)	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.