Description

Ac-Asn(Trt)-OH is a protected asparagine derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with precise sequence control. It is primarily utilized by the pharmaceutical, biotechnology, and research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Peptide Synthesis: A critical intermediate in the Fmoc/t-Bu solid-phase synthesis of peptides containing asparagine residues.
• Pharmaceutical Research: Used in the research and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a modified amino acid for creating custom peptide conjugates for drug delivery systems or diagnostic probes.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening and drug discovery.
• Academic & Industrial R&D: A standard reagent in laboratories focused on protein engineering, structural biology, and chemical biology studies.

Basic Information

Product Name	Ac-Asn(Trt)-OH
CAS No.	163277-78-9
Molecular Formula	C27H28N2O4
Molecular Weight	444.53 g/mol
Synonyms	N-Acetyl-N'-trityl-L-asparagine; Acetyl-L-asparagine N'-trityl; Nα-Acetyl-Nβ-trityl-L-asparagine; Ac-Asn(Trt)-OH; N-Acetyl-N-tritylasparagine; L-Asparagine, N-acetyl-N-trityl-; N-Acetyl-2-tritylamino-3-carbamoylpropanoic acid; Fmoc SPPS Building Block (related)
EINECS	Contact for details

Quality Control

Our Ac-Asn(Trt)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.