Description

3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-, Hydrate is a high-purity, complex heterocyclic compound designed for advanced pharmaceutical research and development. This molecule is a key synthetic intermediate, valued for its intricate stereochemistry and functional groups that are critical for constructing potent active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers and R&D organizations engaged in the discovery and synthesis of novel antibacterial agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of next-generation fluoroquinolone antibiotics and other antimicrobial agents.
• Active Pharmaceutical Ingredient (API) Research: Serves as a core structural component in the development of new drug candidates targeting bacterial DNA gyrase and topoisomerase IV.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale production for new chemical entities (NCEs).
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic & Institutional Research: Utilized in university and institutional labs for medicinal chemistry studies and structure-activity relationship (SAR) analysis.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-, Hydrate
CAS No.	163253-37-0
Molecular Formula	C20H20ClF2N3O3 • xH2O
Molecular Weight	423.84 g/mol (Anhydrous basis)
Synonyms	(1R,2S)-1-(2-Fluorocyclopropyl)-8-chloro-6-fluoro-7-((7S)-7-amino-5-azaspiro[2.4]heptan-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrate; WCK 771 Hydrate (Intermediate); Nadifloxacin Intermediate; 7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrate; Antibacterial Quinolone Intermediate; Sparfloxacin-related intermediate; Fluoroquinolone Spirocyclic Amine Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, NMR, and MS for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical synthesis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (Anhydrous basis)
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	As per COA (Hydrate form)
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.