Description

3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-, Hydrate (2:1) is a high-purity, structurally complex active pharmaceutical ingredient (API) and advanced pharmaceutical intermediate. This compound is critical for its role as a key building block in the synthesis of next-generation antibacterial agents, particularly novel quinolone and fluoroquinolone antibiotics. It is essential for pharmaceutical R&D and manufacturing organizations focused on developing innovative anti-infective therapies to address antibiotic resistance.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core intermediate in the production of advanced fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design and synthesis of novel antibacterial compounds targeting DNA gyrase and topoisomerase IV.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale synthetic routes for new drug candidates.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations producing clinical trial materials or commercial API batches.
• Reference Standard: Utilized as a high-purity chemical reference standard for analytical method development, validation, and quality control.
• Academic & Institutional Research: Supports biochemical and microbiological studies investigating mechanisms of antibiotic action and resistance.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 7-[(7S)-7-Amino-5-Azaspiro[2.4]Hept-5-Yl]-8-Chloro-6-Fluoro-1-[(1R,2S)-2-Fluorocyclopropyl]-1,4-Dihydro-4-Oxo-, Hydrate (2:1)
CAS No.	163253-36-9
Molecular Formula	C₂₁H₂₂ClF₂N₃O₃ · ½H₂O
Molecular Weight	434.87 g/mol (anhydrous basis)
Synonyms	(7S)-7-Amino-5-azaspiro[2.4]heptan-5-yl Derivative of Quinolonecarboxylic Acid; 8-Chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-7-[(7S)-7-amino-5-azaspiro[2.4]hept-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Hydrate; Advanced Fluoroquinolone Intermediate; Spirocyclopropyl Quinolone Intermediate; Antibacterial API Intermediate CAS 163253-36-9; Dihydro-4-oxo-3-quinolinecarboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and impurity profiling, NMR and MS for structural confirmation, and KF titration for water content. We provide full traceability and Certificates of Analysis (COA) that detail all specifications and test results, ensuring compliance with the stringent requirements of pharmaceutical development and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	2.0% - 5.0% (as hydrate)
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.