Description

Sitafloxacin Sesquihydrate CAS NO 163253-35-8 is a broad-spectrum fluoroquinolone antibiotic in its sesquihydrate form, offering enhanced stability and consistent performance in pharmaceutical manufacturing. This compound is critical for developing advanced antibacterial therapies targeting resistant pathogens. It is primarily required by pharmaceutical R&D laboratories, API manufacturers, and contract research organizations (CROs) focused on anti-infective drug development.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of oral and injectable antibacterial medications.
• Reference Standard in analytical laboratories for quality control and method development of fluoroquinolone-based drugs.
• Research & Development of novel antibiotic compounds and combination therapies to combat multi-drug resistant bacterial infections.
• Pharmacological Studies investigating the efficacy, pharmacokinetics, and mechanism of action of advanced-generation quinolones.
• Veterinary Pharmaceutical Development for creating antibacterial treatments for animal health.

Basic Information

Product Name	Sitafloxacin Sesquihydrate
CAS No.	163253-35-8
Molecular Formula	C₁₉H₁₈ClF₂N₃O₃ • 1.5 H₂O
Molecular Weight	428.82 g/mol (anhydrous basis)
Synonyms	Sitafloxacin Hydrate; DU-6859a; (1S,5R,6S)-8-fluoro-1-(1-fluorocyclopropyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid sesquihydrate; Sitafloxacin 1.5 hydrate; Sitafloxacin hemihydrate; Gracevit; T-3811
EINECS	Contact for details

Quality Control

Our Sitafloxacin Sesquihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided, confirming identity, purity, and impurity profiles as per in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	5.0% - 7.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.