Description

L-Leucine, 5,5-Dihydroxy- (9Ci) is a specialized derivative of the essential amino acid L-leucine, featuring two hydroxyl groups at the 5-position. This unique molecular structure makes it a valuable chiral building block and intermediate for advanced organic synthesis and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptide Synthesis: Used in the preparation of modified peptides and peptidomimetics, where the dihydroxy-leucine moiety can influence conformation, solubility, and bioactivity.
• Bioconjugation & Probe Development: Acts as a functional handle for bioconjugation chemistry in the creation of diagnostic probes, imaging agents, and antibody-drug conjugates (ADCs).
• Agrochemical Research: Employed as a building block in the synthesis of novel herbicides, fungicides, or plant growth regulators with improved selectivity.
• Biochemical Research: Used in enzymatic studies and as a substrate analog to investigate metabolic pathways involving leucine metabolism.
• Material Science: Potential monomer for synthesizing novel biodegradable polymers or functional materials with specific chiral properties.

Basic Information

Product Name	L-Leucine, 5,5-Dihydroxy- (9Ci)
CAS No.	163190-39-4
Molecular Formula	C6H13NO4
Molecular Weight	163.17 g/mol
Synonyms	5,5-Dihydroxy-L-leucine; (2S)-2-Amino-5,5-dihydroxyhexanoic acid; L-5,5-Dihydroxyleucine; 5,5-Dihydroxyleucine; (S)-2-Amino-5,5-dihydroxyhexanoic acid; 5,5-Dihydroxy-L-leucine (9CI); 5,5-Dihydroxynorleucine; 2-Amino-5,5-dihydroxyhexanoic acid
EINECS	Contact for details

Quality Control

Our L-Leucine, 5,5-Dihydroxy- (9Ci) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.