Description

4H-Quinolizine-3-Carboxylicacid, 8-[(3S)-3-Amino-1-Pyrrolidinyl]-1-Cyclopropyl-7-Fluoro-9-Methyl-4-Oxo-,Hydrochloride (1:1) is a high-purity, complex fluoroquinolone derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical advanced pharmaceutical intermediate for the synthesis of novel antibacterial agents. It is primarily required by R&D laboratories and manufacturers in the pharmaceutical industry focused on developing next-generation therapeutics.

Application

• Key Intermediate for Antibacterial API Synthesis: Serves as a crucial building block in the multi-step synthesis of novel fluoroquinolone-class active pharmaceutical ingredients (APIs).
• Pharmaceutical Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the development of new antibacterial candidates.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale production of experimental drug substances.
• Reference Standard: Can be utilized as a high-purity analytical reference standard for quality control and method development in API manufacturing.

Basic Information

Product Name	4H-Quinolizine-3-Carboxylicacid, 8-[(3S)-3-Amino-1-Pyrrolidinyl]-1-Cyclopropyl-7-Fluoro-9-Methyl-4-Oxo-,Hydrochloride (1:1)
CAS No.	162763-53-3
Molecular Formula	C19H23FN4O3 • HCl
Molecular Weight	410.87 g/mol (Free base: 374.41 g/mol)
Synonyms	1-Cyclopropyl-7-fluoro-9-methyl-8-[(3S)-3-amino-1-pyrrolidinyl]-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride; (3S)-8-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride; Fluoroquinolone Derivative Intermediate; Quinolizinecarboxylic acid derivative hydrochloride; ABT-492 Intermediate (related compound); 8-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxoquinolizine-3-carboxylic acid hydrochloride (S-isomer)
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.