Description

Melagatran is a potent, direct-acting thrombin inhibitor, representing a significant advancement in anticoagulant therapy. Its primary value lies in its ability to prevent and treat thrombotic events by directly and selectively inhibiting thrombin, a key enzyme in the blood coagulation cascade. This product is essential for pharmaceutical research and development, particularly for scientists and manufacturers focused on next-generation anticoagulant drugs, prodrug development, and biochemical studies of hemostasis.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active component in the research and development of novel anticoagulant medications.
• Biochemical Research: Used as a highly specific tool compound to study thrombin's role in coagulation pathways, enzyme kinetics, and receptor interactions in vitro.
• Prodrug Synthesis: Acts as the active moiety for the chemical synthesis and evaluation of prodrug candidates, such as ximelagatran, designed for improved oral bioavailability.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development, validation, and impurity profiling.
• Mechanistic Studies: Facilitates research into thrombosis models, helping to elucidate mechanisms of action for antithrombotic agents.

Basic Information

Product Name	Melagatran
CAS No.	162694-63-5
Molecular Formula	C19H28N6O4
Molecular Weight	404.47 g/mol
Synonyms	H 376/95; (2S)-2-[[(2S)-4-[[(aminoiminomethyl)amino]methyl]-2-[[(1R)-2-carboxy-1-cyclohexyl-2-oxoethyl]amino]butanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid; (2S)-2-[[(2S)-4-(Carbamimidamidemethyl)-2-[[(1R)-1-cyclohexyl-2-carboxy-2-oxo-ethyl]amino]butanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid; Melagatranum
EINECS	Contact for details

Quality Control

Our Melagatran is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the full suite of test results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.