Description

H-D-Tyr(3-Cl)-Oh is a non-natural, chlorinated derivative of the amino acid tyrosine, specifically designed for advanced peptide synthesis and pharmaceutical research. This modified amino acid is crucial for introducing specific structural and electronic properties into peptide chains, enabling the fine-tuning of biological activity and stability. It is an essential building block for researchers and manufacturers in the fields of peptide-based drug discovery, bioconjugation, and the development of novel biochemical probes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel therapeutic peptides and peptidomimetics.
• Drug Discovery Research: Used to incorporate chlorotyrosine residues into peptide sequences to study structure-activity relationships (SAR) and modulate receptor binding.
• Bioconjugation & Labeling: Serves as a precursor for creating specialized linkers or tags for antibody-drug conjugates (ADCs) or diagnostic agents.
• Biochemical Tool Development: Employed in the design of enzyme inhibitors, receptor agonists/antagonists, and other bioactive research compounds.
• Material Science: Potential use in the synthesis of functionalized polymers and advanced biomaterials with specific chemical handles.

Basic Information

Product Name	H-D-Tyr(3-Cl)-Oh
CAS No.	162599-96-4
Molecular Formula	C9H10ClNO3
Molecular Weight	215.63 g/mol
Synonyms	D-3-Chlorotyrosine; (R)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; H-D-Tyr(3-Cl)-OH; D-Tyr(3-Cl)-OH; D-3-Chloro-L-tyrosine; (2R)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid; D-3-Chlorotyrosine-OH
EINECS	Contact for details

Quality Control

Our H-D-Tyr(3-Cl)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.