Description

n-Fmoc-N'-Boc-L-2,3-Diaminopropionic Acid is a high-purity, dual-protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is specifically engineered to provide orthogonal protection for the alpha and beta amino groups, enabling precise, sequential deprotection and controlled peptide chain elongation. It is a critical building block for researchers and manufacturers developing complex peptides, peptidomimetics, and bioconjugates for pharmaceutical discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid monomer for the controlled, sequential assembly of peptides, particularly those requiring branched or modified structures.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Serves as a precursor for creating non-natural amino acid residues that enhance the metabolic stability and bioavailability of peptide drugs.
• Bioconjugation and Linker Chemistry: The orthogonal protecting groups (Fmoc and Boc) allow for selective functionalization, making it useful for attaching peptides to surfaces, carriers, or other molecules.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.

Basic Information

Product Name	n-Fmoc-N'-Boc-L-2,3-Diaminopropionic Acid
CAS No.	162558-25-0
Molecular Formula	C24H28N2O6
Molecular Weight	440.49 g/mol
Synonyms	Fmoc-Dap(Boc)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)propanoic Acid; Nα-Fmoc-Nβ-Boc-L-2,3-diaminopropionic Acid; Boc-Dap(Fmoc)-OH; L-2,3-Diaminopropionic Acid, Nα-Fmoc, Nβ-Boc; Fmoc-L-Dap(Boc)-OH; N-Fmoc-N'-Boc-L-2,3-diaminopropanoic Acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-N'-Boc-L-2,3-Diaminopropionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the exacting standards required for advanced peptide synthesis. Certificates of Analysis (COA) with full chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach ambient temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.