Description

Urea, n-[1-Cyclohexyl-2,3,4,5-Tetrahydro-2,4-Dioxo-5-[2-Oxo-2-(1-Pyrrolidinyl)Ethyl]-1H-1,5-Benzodiazepin-3-Yl]-N'-(4-Fluorophenyl)- is a sophisticated, high-purity organic compound with the CAS registry number 162271-52-5. This specialized chemical serves as a critical advanced intermediate in the synthesis of complex active pharmaceutical ingredients (APIs) and fine chemicals. It is essential for research and development organizations, pharmaceutical manufacturers, and fine chemical producers requiring highly specific molecular architectures for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzodiazepine-derived therapeutic agents and other complex drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Fine Chemical Synthesis: Serves as a precursor for creating specialized compounds used in agrochemicals, materials science, and advanced organic synthesis.
• Biochemical Research: Potential use as a tool compound or ligand in biochemical assays and target validation studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	Urea, n-[1-Cyclohexyl-2,3,4,5-Tetrahydro-2,4-Dioxo-5-[2-Oxo-2-(1-Pyrrolidinyl)Ethyl]-1H-1,5-Benzodiazepin-3-Yl]-N'-(4-Fluorophenyl)-
CAS No.	162271-52-5
Molecular Formula	C28H30FN5O4
Molecular Weight	519.57 g/mol
Synonyms	1-Cyclohexyl-3-[(4-fluorophenyl)carbamoyl]-5-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1,5-dihydro-2H-1,5-benzodiazepine-2,4-dione; 1-Cyclohexyl-5-[2-oxo-2-(1-pyrrolidinyl)ethyl]-3-[[(4-fluorophenyl)amino]carbonyl]-1,5-dihydro-2H-1,5-benzodiazepine-2,4-dione; 162271-52-5; Benzodiazepine urea derivative; N-(4-Fluorophenyl)-N'-[1-cyclohexyl-2,3,4,5-tetrahydro-2,4-dioxo-5-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1H-1,5-benzodiazepin-3-yl]urea
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates and relevant ICH stability requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.