Description

1-Bromo-4-Fluoro-2-(Methoxymethoxy)Benzene is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a protected hydroxyl group, makes it a versatile intermediate for constructing complex molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores essential in electronic display and lighting technologies.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Protecting Group Chemistry: The methoxymethoxy (MOM) group acts as a robust protecting group for phenols, which can be selectively deprotected under mild acidic conditions.
• Material Science Research: Employed in the development of novel polymers and ligands with specific electronic or steric properties.

Basic Information

Product Name	1-Bromo-4-Fluoro-2-(Methoxymethoxy)Benzene
CAS No.	162269-78-5
Molecular Formula	C8H8BrFO2
Molecular Weight	235.05 g/mol
Synonyms	2-Bromo-5-fluoroanisole, MOM-protected; 4-Fluoro-2-(methoxymethoxy)-1-bromobenzene; 1-Bromo-4-fluoro-2-(methoxymethoxy)benzene; 2-(Methoxymethoxy)-4-fluorobromobenzene; Benzene, 1-bromo-4-fluoro-2-(methoxymethoxy)-; [1-Bromo-4-fluoro-2-(methoxymethoxy)phenyl] (IUPAC-style); MOM-protected 2-Bromo-5-fluorophenol
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Fluoro-2-(Methoxymethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO standards for pharmaceutical and industrial applications, ensuring reliable supply for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed in a dry and inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.