Description

5-Trifluoromethylindoline is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique electronic and steric properties imparted by the trifluoromethyl group, which is crucial for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the CF3 group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a building block for specialty chemicals, liquid crystals, and functional polymers.
• Organic Light-Emitting Diode (OLED) Materials: Employed in the synthesis of electron-transport or host materials for display technologies.
• Fluorine Chemistry Research: An important substrate for studying novel fluorination reactions and developing new catalytic methodologies.
• Ligand and Catalyst Development: Used to construct sophisticated chiral or non-chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	5-Trifluoromethylindoline
CAS No.	162100-55-2
Molecular Formula	C9H8F3N
Molecular Weight	187.16 g/mol
Synonyms	5-(Trifluoromethyl)indoline; 2,3-Dihydro-5-(trifluoromethyl)-1H-indole; 1H-Indole, 2,3-dihydro-5-(trifluoromethyl)-; Indoline, 5-(trifluoromethyl)-; 5-Trifluoromethyl-2,3-dihydro-1H-indole
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethylindoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring GMP-grade starting materials and compliance with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.