Description

3,4-Difluoro-2-Iodoaniline is a high-purity, multi-functional halogenated aniline derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring iodine and fluorine substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and cross-coupling reactions (e.g., Buchwald-Hartwig amination).
• Material Science Research: Building block for organic electronic materials, such as charge-transport molecules, OLED components, and liquid crystals.
• Chemical Biology Probes: Used to synthesize fluorescent tags, radiolabeled compounds (using I-127 or as a precursor for I-125), and other molecular probes for diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring specific halogenated aniline motifs.

Basic Information

Item	Details
Product Name	3,4-Difluoro-2-Iodoaniline
CAS No.	161958-41-4
Molecular Formula	C6H4F2IN
Molecular Weight	255.01 g/mol
Synonyms	2-Iodo-3,4-difluoroaniline; 3,4-Difluoro-2-iodobenzenamine; 2-Amino-1,2-difluoro-4-iodobenzene; Benzenamine, 3,4-difluoro-2-iodo-; 3,4-Difluoro-2-iodoaniline; 2-Iodo-3,4-difluoro-benzenamine
EINECS	Contact for details

Quality Control

Our 3,4-Difluoro-2-Iodoaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.