Description

(Pyr3)-Amyloid β-Protein (3-40) CAS NO 161818-04-8 is a chemically modified peptide fragment derived from the amyloid beta protein, a key molecule in neurological research. This specific pyroglutamate-modified variant is critical for studying the aggregation mechanisms and neurotoxic properties associated with amyloid plaques. It serves as an essential biochemical tool for researchers and developers in the fields of neuroscience, pharmacology, and diagnostic assay development. The compound is particularly valuable for creating more accurate in vitro models of protein misfolding diseases.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, structure, and toxicity of amyloid beta peptides in Alzheimer's disease pathology.
• Drug Discovery & Screening: Used as a target or reagent in high-throughput screening assays to identify potential therapeutic compounds that inhibit aggregation or promote clearance.
• Diagnostic Development: Serves as a critical antigen or standard in the development and calibration of immunoassays (ELISA, Western Blot) for detecting amyloid beta variants in biological samples.
• Antibody Production & Characterization: Acts as an immunogen for generating specific antibodies or as a reference standard for validating antibody specificity against pyroglutamate-modified amyloid beta.
• Biophysical Studies: Utilized in techniques like NMR, circular dichroism (CD), and surface plasmon resonance (SPR) to investigate peptide conformation and interaction dynamics.
• Cell Culture & Toxicology: Applied in neuronal cell culture models to induce and study amyloid-β-mediated cytotoxicity and cellular pathways.

Basic Information

Product Name	(Pyr3)-Amyloid β-Protein (3-40)
CAS No.	161818-04-8
Molecular Formula	C185H281N53O58S
Molecular Weight	~4180.6 g/mol
Synonyms	pGlu3-Aβ(3-40); Pyroglutamate-3 Amyloid β-Protein (3-40); Aβ3-40 (pE3); N-Terminally Truncated pyroGlu-3 Aβ3-40; Amyloid Beta Peptide (3-40) (pGlu3); 1-38 fragment of Amyloid β-Protein with N-terminal pGlu; pE-Aβ(3-40)
EINECS	Contact for details

Quality Control

Every batch of (Pyr3)-Amyloid β-Protein (3-40) is produced and analyzed under stringent quality protocols to ensure identity, purity, and batch-to-batch consistency suitable for critical research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity, peptide content, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated at -20°C or below. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Retention time and mass consistent with reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Molecular Weight	4175 - 4185 g/mol (by mass spectrometry)
Solubility	Soluble in water, dilute acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.