Description

1,2,4-Triazolo[4,3-A]Pyrimidin-7(1H)-One, 5-Mercapto- is a heterocyclic organic compound featuring a fused triazolopyrimidine core with a reactive mercapto group. This specialized structure makes it a valuable key intermediate and building block in advanced organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D departments, agrochemical manufacturers, and fine chemical synthesis specialists seeking to incorporate its unique scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, antiviral agents, and anti-inflammatory compounds.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Material Science Chemistry: Used in the research and development of advanced organic materials, such as ligands for catalysis or components in organic electronics.
• Bioconjugation & Probe Synthesis: The reactive mercapto (-SH) group allows for site-specific conjugation, useful in creating biochemical probes and labeled compounds for diagnostic research.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for methodological studies and the exploration of new chemical reactions involving sulfur-containing heterocycles.

Basic Information

Item	Details
Product Name	1,2,4-Triazolo[4,3-A]Pyrimidin-7(1H)-One, 5-Mercapto-
CAS No.	161715-52-2
Molecular Formula	C5H4N4OS
Molecular Weight	168.17 g/mol
Synonyms	5-Mercapto-1,2,4-triazolo[4,3-a]pyrimidin-7(1H)-one; 5-Mercapto-[1,2,4]triazolo[4,3-a]pyrimidin-7-one; 1H-1,2,4-Triazolo[4,3-a]pyrimidin-7-one, 5-mercapto-; 5-Thiol-1,2,4-triazolo[4,3-a]pyrimidin-7(1H)-one; [1,2,4]Triazolo[4,3-a]pyrimidine-7(1H)-one, 5-mercapto-; 5-Sulfanyl-[1,2,4]triazolo[4,3-a]pyrimidin-7-ol (tautomer); TZP-SH derivative
EINECS	Contact for details

Quality Control

Our 1,2,4-Triazolo[4,3-A]Pyrimidin-7(1H)-One, 5-Mercapto- is produced under a strict quality management system. Each batch undergoes rigorous analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged procedures to prevent oxidation of the mercapto group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.