Description

3-(2,2,2-Trifluoroethyl)Phenol is a fluorinated phenolic compound that serves as a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring a phenol group linked to a trifluoroethyl moiety, provides distinct electronic and steric properties critical for developing high-performance materials and active pharmaceutical ingredients. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine for enhanced bioactivity, stability, and material characteristics.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and anti-inflammatory drug candidates where the trifluoroethyl group can improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where fluorine atoms are leveraged to increase efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers and polymers used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to influence polarity and intermolecular interactions.
• Polymer Modification: Incorporated as a functional monomer to create specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and creating libraries of novel compounds for screening.

Basic Information

Product Name	3-(2,2,2-Trifluoroethyl)Phenol
CAS No.	161611-53-6
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	3-(2,2,2-Trifluoroethyl)phenol; 1-(3-Hydroxyphenyl)-2,2,2-trifluoroethane; m-(Trifluoroethyl)phenol; 3-Hydroxybenzyl trifluoride; 2,2,2-Trifluoro-1-(3-hydroxyphenyl)ethane; 3-(Trifluoroethyl)phenol; Phenol, 3-(2,2,2-trifluoroethyl)-
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoroethyl)Phenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with global regulatory frameworks, including REACH, and can provide material for GMP applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.