Description

Cyclo (Arg-Gly-Asp-D-Phe-Lys) is a synthetic cyclic pentapeptide containing the Arg-Gly-Asp (RGD) motif. This compound is a highly specific and potent inhibitor of integrin-mediated cell adhesion processes, making it a critical research tool in cell biology and drug discovery. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for studying angiogenesis, tumor metastasis, and as a lead compound in the development of novel therapeutics.

Application

• Biomedical Research: Used as a selective antagonist to study the role of αvβ3 and αvβ5 integrins in cell adhesion, migration, and signaling pathways.
• Angiogenesis Studies: Applied in in vitro and in vivo models to inhibit endothelial cell adhesion and investigate mechanisms of blood vessel formation.
• Cancer Research: Employed to block tumor cell attachment and invasion, providing insights into metastasis and potential anti-cancer strategies.
• Drug Discovery: Serves as a reference standard and a structural scaffold for the design and development of new anti-thrombotic and anti-angiogenic drugs.
• Biomaterial Functionalization: Used to coat surfaces to modulate cell-material interactions in tissue engineering and implant development.

Basic Information

Product Name	Cyclo (Arg-Gly-Asp-D-Phe-Lys)
CAS No.	161552-03-0
Molecular Formula	C27H41N9O7
Molecular Weight	603.68 g/mol
Synonyms	c(RGDfK); Cyclo(-Arg-Gly-Asp-D-Phe-Lys-); cRGDfK; Cyclo(RGD-D-Phe-Lys); Cyclo(Arg-Gly-Asp-D-Phe-Lys); Cyclopentapeptide RGDfK; RGD Cyclic Peptide; Integrin αvβ3 Antagonist (cRGDfK)
EINECS	Contact for details

Quality Control

Our Cyclo (Arg-Gly-Asp-D-Phe-Lys) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Analysis	Conforms
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.