Description

Fmoc-L-Alaninol CAS NO 161529-13-1 is a protected amino alcohol derivative, serving as a crucial chiral building block in organic synthesis. This compound is essential for the controlled introduction of the alanine side chain with a free hydroxyl group, enabling the construction of complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and peptide synthesis industries for developing novel therapeutics and advanced materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the incorporation of alaninol residues into peptide chains, particularly in the synthesis of peptide nucleic acids (PNAs) and other modified peptides.
• Pharmaceutical Intermediates: Serves as a vital precursor in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, especially those requiring chiral amino alcohol functionalities.
• Ligand and Catalyst Preparation: Used to synthesize chiral ligands for asymmetric catalysis and organocatalysts, leveraging its stereogenic center and functional groups.
• Bioconjugation and Linker Chemistry: The Fmoc-protected amine and free alcohol allow for selective modifications, making it valuable for creating drug-linker systems in antibody-drug conjugates (ADCs).
• Material Science Research: Employed in the development of novel polymers, dendrimers, and functional surfaces where precise molecular recognition is required.
• Chemical Biology Probes: Acts as a building block for fluorescent tags, affinity probes, and other tools used to study biological processes and protein interactions.

Basic Information

Product Name	Fmoc-L-Alaninol
CAS No.	161529-13-1
Molecular Formula	C₁₈H₁₉NO₃
Molecular Weight	297.35 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alaninol; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]propan-1-ol; Fmoc-L-2-Amino-1-propanol; Fmoc-L-Ala-ol; Fmoc-Alaninol; N-Fmoc-L-alaninol; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propan-1-ol; L-Alaninol, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-L-Alaninol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and spectroscopic identification (NMR, IR). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment ensures the material meets the high standards required for research and cGMP-grade pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.